 | 1920 | 1921 | 1922 |  |
Date | Country | Change |
| 1921 |  Albania | Titular Episcopal See of Craina was restored |
| 1921 |  Bulgaria | Titular Episcopal See of Apiaria was renamed as Titular Episcopal See of Apiara |
| 1921 |  Greece | Titular Episcopal See of Dobero was renamed as Titular Episcopal See of Doberas |
| 1921 | Greece | Titular Episcopal See of Kefalonia was suppressed |
| 1921 | Greece | Titular Episcopal See of Ænos was renamed as Titular Episcopal See of Ænus s. Hænus |
| 1921 |  Israel | Titular Archiepiscopal See of Helenopolis was established |
| 1921 |  Moldova,  Russia | Diocese of Tiraspol lost territory to Diocese of Iaşi |
| 1921 |  Poland | Diocese of Augustów lost territory to Diocese of Žemaitija |
| 1921 |  Switzerland | Apostolic Prefecture of Rhaetia was suppressed (to Diocese of Chur) |
| 1921 |  Tunisia | Titular Archiepiscopal See of Carie Portus was established |
| 1921 |  Turkiye | Titular Episcopal See of Camachus was renamed as Titular Episcopal See of Chamacus |
| 1921 | Turkiye | Titular Episcopal See of Charræ was renamed as Titular Episcopal See of Charriæ |
| 1921 | Turkiye | Titular Episcopal See of Colybrassus was renamed as Titular Episcopal See of Colybranus |
| 1921 | Turkiye | Titular Episcopal See of Theodoropolis was established |
| 1921 | Turkiye | Titular Episcopal See of Theodosiopolis (Greek Rite) was renamed as Titular Episcopal See of Theodoropolis |
| 1921 | Turkiye | Titular Archiepiscopal See of Verissa was restored |
| 1921 |  Ukraine | Titular Episcopal See of Lutsk–Ostroh (Ukrainian Rite) was restored |
| 1921 | Titular Episcopal See of Pacanda was suppressed | |
| 1921.01.10 |  Algeria | Apostolic Prefecture of Ghardaïa was renamed as Apostolic Prefecture of Ghardaïa nel Sahara |
| 1921.01.10 |  Angola | Apostolic Prefecture of Upper Cimbebasia in Portuguese Angola was renamed as Apostolic Prefecture of Cubango in Angola |
| 1921.01.10 |  Madagascar | Apostolic Vicariate of Betafó was renamed as Apostolic Vicariate of Antsirabé |
| 1921.01.10 |  Namibia | Apostolic Prefecture of Lower Cimbebasia was renamed as Apostolic Prefecture of Cimbebasia |
| 1921.02.11 |  Brazil | Diocese of Belo Horizonte was established (from Metropolitan Archdiocese of Mariana and became suffragan of Mariana) |
| 1921.02.16 |  Costa Rica | Diocese of Alajuela was established (from Diocese of San José and became suffragan of San José) |
| 1921.02.16 | Costa Rica | Apostolic Vicariate of Limón was established (from Diocese of San José and became suffragan of San José) |
| 1921.02.16 | Costa Rica | Diocese of San José was promoted as Metropolitan Archdiocese of San José (with suffragan sees Alajuela and Limón and lost territory to establish Diocese of Alajuela and Apostolic Vicariate of Limón) |
| 1921.02.22 |  Peru | Apostolic Prefecture of Putumayo was suppressed (to Apostolic Vicariate of San León del Amazonas) |
| 1921.02.22 | Peru | Apostolic Prefecture of San León del Amazonas was promoted as Apostolic Vicariate of San León del Amazonas (gained territory from the suppressed Apostolic Prefecture of Putumayo) |
| 1921.02.27 | Peru | Apostolic Prefecture of San Gabriel de la Dolorosa del Marañón was established (from Apostolic Vicariate of San León del Amazonas) |
| 1921.03 |  Congo-Kinshasa | Apostolic Vicariate of Kasaï Supérieur lost territory to Apostolic Prefecture of Kwango |
| 1921.03.01 |  Germany | Apostolic Vicariate of Anhalt was suppressed (to Diocese of Paderborn) |
| 1921.03.21 |  Italy | Archdiocese of Gaeta lost territory to Diocese of Veroli |
| 1921.04.30 |  Canada | Diocese of Prince Albert was renamed as Diocese of Prince Albert–Saskatoon |
| 1921.05.06 | Canada | Territorial Abbacy of Saint Peter–Muenster was established (from Diocese of Prince Albert–Saskatoon and became suffragan of Regina) |
| 1921.05.13 |  Colombia | Apostolic Prefecture of Tierradentro was established (from Metropolitan Archdiocese of Popayán) |
| 1921.05.27 | Brazil | Metropolitan Archdiocese of Porto Alegre exchanged territory with Diocese of Santa Maria |
| 1921.05.27 | Brazil | Diocese of Santa Maria exchanged territory with Metropolitan Archdiocese of Porto Alegre and Diocese of Uruguaiana |
| 1921.05.27 | Brazil | Diocese of Uruguaiana exchanged territory with Diocese of Santa Maria |
| 1921.06.01 |  China | Apostolic Vicariate of Fuzhou 撫州 was renamed as Apostolic Vicariate of Yujiang 餘江 |
| 1921.06.24 | Germany | Apostolic Prefecture of Lausitz was suppressed (to Diocese of Meißen) |
| 1921.06.24 | Germany | Apostolic Vicariate of Meißen was promoted as Diocese of Meißen (gained territory from the suppressed Apostolic Prefecture of Lausitz and without ecclesiastical province) |
| 1921.07.02 |  Burkina Faso | Apostolic Vicariate of Ouagadougou was established (from Apostolic Vicariate of French Sudan) |
| 1921.07.02 |  Mali | Apostolic Vicariate of French Sudan was renamed as Apostolic Vicariate of Bamako (lost territory to establish Apostolic Vicariate of Ouagadougou) |
| 1921.07.27 |  Guatemala | Diocese of Quetzaltenango, Los Altos was established (from Metropolitan Archdiocese of Guatemala and became suffragan of Guatemala) |
| 1921.07.27 | Guatemala | Apostolic Vicariate of Verapaz and Petén was restored (from Metropolitan Archdiocese of Guatemala and became suffragan of Guatemala) |
| 1921.07.30 |  Belgium | Apostolic Administration of Eupen–Malmedy–Sankt Vith was promoted as Diocese of Eupen–Malmedy (became suffragan of Mechelen) |
| 1921.08.08 | China | Apostolic Vicariate of Anhui 安徽 was established (from Apostolic Vicariate of Jiangnan 江南) |
| 1921.08.08 | China | Apostolic Vicariate of Jiangnan 江南 was renamed as Apostolic Vicariate of Jiangsu 江蘇 (lost territory to establish Apostolic Vicariate of Anhui 安徽) |
| 1921.08.27 |  South Africa | Apostolic Prefecture of Zululand was established (from Apostolic Vicariate of Natal) |
| 1921.09.10 | South Africa | Apostolic Vicariate of Mariannhill was established (from Apostolic Vicariate of Natal) |
| 1921.09.30 | Italy | Metropolitan Archdiocese of Conza lost territory to Diocese of Campagna |
| 1921.12.01 | Russia | Apostolic Vicariate of Siberia was established (from Metropolitan Archdiocese of Mohilev) |
| 1921.12.02 | Brazil | Diocese of São Luís do Maranhão was promoted as Archdiocese of São Luís do Maranhão |
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